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Researchers Found Blood Holds Key To Regeneration Of Liver

The liver is the only body organ that can rejuvenate. But some people who undergo a liver resection, an operation that eliminates a diseased part of the organ, end up requiring a transplant due to fact that the renewal procedure does not work.

A new study by Michigan State University, posted in the Blood journal, displays that the fibrinogen (blood-clotting protein) might hold the key as to why this takes place.

“We found that fibrinogen builds up inside the rest of the liver swiftly after surgery and informs platelets to react as first responders, activating the earliest stage of renovation,” claimed a professor in the College of Veterinary Medicine for pathobiology, James Luyendyk, to the media in an interview. “But if platelets or fibrinogen are inhibited, then renovation is postponed.”

Platelets are blood cells that assist stop bleeding and form clots. When they get data from fibrinogen, they go into action and build up in the rest of the liver’s part to assist recreate it, elevating the odds of a completely operational liver and unbeaten recovery.

On a related note, scientists at TIFR have found molecular expectancy of feeding in the liver that is important to make sure that the body adapts to use arriving nutrients after fasting upon re-feeding. Their results, posted in the Cell Reports international journal, display that very tiny RNA molecules dubbed as microRNAs regulate primary metabolic pathways by reducing synthesis of proteins, and thus add to blood glucose levels maintenance.

Liver is one of the vital metabolic organs that have a major role in preserving lifespan and organismal health. All living beings go from feed-fast cycles, where fats are broken fragmented during fasting to meet the energy requirements while carbohydrates or glucose act as primary source of energy after consumption of food. Inflexibility to swing between these procedures arrives from the failure of organisms or organs to change metabolic pathways.